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Common (Usually Transient) Side Effects Water retention or puffiness Carpal tunnel-like symptoms Joint stiffness (often temporary) Mild insulin resistance if overdosed How We Monitor Baseline and follow-up IGF-1 levels Body composition changes Symptom tracking and dose titration Our goal is to maintain IGF-1 in the high-normal physiologic range , not to create supraphysiologic levels

Should people with MTHFR take folic acid

Increased HIF-1 activity is also observed for other iron chelators, such as salicylaldehyde isonicotinoyl hydrazone (SIH) and deferiprone (Creighton-Gutteridge and Tyrrell, 2002)

10.1126/science.1077209 Science 20 BrakedalB.FlnesI.ReiterS